EACVI-MMVD Study
The first international prospective study
dedicated to Multiple and Mixed Valvular Diseases
The MMVD Study is a prospective international registry designed to better understand how multiple and mixed valvular disease presents and evolves in real life. The study collects clinical information and multimodality imaging from patients across dozens of centers worldwide, allowing us to capture the full spectrum of this complex condition. By bringing together data from different countries and healthcare systems, the project aims to clarify current practices, identify prognostic markers, and support future evidence-based recommendations.
“Multiple and mixed valvular disease is a daily reality for clinicians, yet remains one of the least explored areas in valvular cardiology. With this study, we finally bring global attention and data to a condition that urgently needs it.”
Dr Théo Pezel
Lariboisière Hospital, AP-HP (Paris, France)
Lead Principal Investigator
The MMVD Study includes all consecutive patients referred to a Cardiovascular imaging Department with a diagnosis of at least one at least moderate valvular heart disease (VHD), and who meet the criteria for MMVD defined by multiple and/or mixed disease.
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Patients Included
Our Global Network
The MMVD Study is powered by the enthusiasm and collaborative spirit of the Heart Imagers of Tomorrow (HIT) community of the EACVI. Young and experienced cardiovascular imagers have joined forces to build the first worldwide registry dedicated to multiple and mixed valvular disease.
This shared effort brings together centers from more than 20 countries, each contributing real-world data, diverse clinical perspectives, and unique imaging expertise. Together, we are creating an unprecedented global picture of MMVD — one that reflects how patients are assessed, imaged, and treated across different healthcare systems and cultures.
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👆 Click on any marker to discover participating centers!
Meet Our 10 Coordinators
A huge thank you to our incredible Coordinators! 🙏
They played a key role in setting up the study across borders — coordinating local contracts, reaching out to new centers, and helping build our global network. Thanks to their dedication and enthusiasm, the EACVI-MMVD Study successfully enrolled patients from over 20 countries worldwide!
University of Medicine and Pharmacy of Craiova
🇷🇴
Medical University of Warsaw
🇵🇱
CHRU de Lille - Institut Cœur Poumon
🇫🇷
CHU Lariboisière (AP-HP)
🇫🇷
Juntendo University
🇯🇵
Azienda Ospedaliera Universitaria Senese
🇮🇹
CHU Lariboisière (AP-HP)
🇫🇷
Charité Universitätsmedizin - Mitte
🇩🇪
HUB - Hôpital Erasme
🇧🇪
AHEPA Hospital
🇬🇷Meet the researchers and clinicians driving the MMVD Study forward.
Operational Team
Dr Théo Pezel
Lead PI
🇫🇷
Camille Fourcault
eCRF Manager
🇫🇷
Christine Pereira
Contracts Coordinator
🇫🇷
Solenn Toupin, PhD
Data Science & Imaging Lead
🇫🇷
Dr Alexandre Unger
Study Management & Biostatistics
🇫🇷
Pr Eric Vicaut
Methodologist
🇫🇷
Steering Committee
University of Medicine and Pharmacy of Craiova
🇷🇴Ogaki Municipal Hospital
🇯🇵
Azienda Ospedaliera Universitaria Integrata
🇮🇹
CHU d'Amiens Sud
🇫🇷Medical University of Warsaw
🇵🇱
Frantz Fanon Hospital
🇩🇿
Institut Universitaire de Cardiologie et de Pneumologie de Québec - Université Laval
🇨🇦CHRU de Lille - Institut Cœur Poumon
🇫🇷
CHU de Rennes - Pontchaillou
🇫🇷CHU Lariboisière (AP-HP)
🇫🇷
Shaheed Rajaie Cardiovascular, Medical & Research Center
🇮🇷Juntendo University
🇯🇵
AHEPA Hospital
🇬🇷Azienda Ospedaliera Universitaria Senese
🇮🇹
Kindai University
🇯🇵
Auxologico San Luca
🇮🇹CHU Lariboisière (AP-HP)
🇫🇷
Institut Universitaire de Cardiologie et de Pneumologie de Québec - Université Laval
🇨🇦
Centro Cardiologico Monzino IRCCS
🇮🇹
Medizinischen Universität (Tirol Kliniken)
🇦🇹Charité Universitätsmedizin - Mitte
🇩🇪Kobe City Hospital Organization General Hospital
🇯🇵HUB - Hôpital Erasme
🇧🇪
CHU Saint Pierre
🇧🇪
Mehmet Akif Ersoy Hospital
🇹🇷
Military Institute of Medicine - National Research Institute
🇵🇱Imaging Core Laboratories
Three specialized Core Laboratories analyzed imaging data from participating centers, ensuring rigorous quality control and standardized measurements across all modalities.
Core Lab of CHU Rennes
Learn more🇫🇷 Rennes, France
Lead Researchers
Pr Erwan Donal
CHU Rennes
Pr Augustin Coisne
CHRU de Lille
Core Lab Team
Lucile Bichot
Clinical Studies Technician
Anne-Sophie Alix-Doucet
Clinical Studies Coordinator
VaRMI Core Lab
Learn more🇨🇦 Laval Hospital, Quebec, Canada
Lead Researcher
Pr Marie-Annick Clavel
Laval Hospital
Core Lab Team
Kathia Abdoun
Vanessa Couture
Sylvie Morin
Andréanne Powers
MIRACL.ai Core Lab
Learn more🇫🇷 AP-HP Platform, Paris, France
Lead Researchers
Dr Théo Pezel
Lariboisière Hospital
Dr Gilles Soulat
HEGP Hospital
Core Lab Team
Solenn Toupin, PhD
Scientific Coordinator
Dr Paul-Jun Martial
Clinical Coordinator
Rationale and Design of EACVI-MMVD Study: An International Registry on Multimodality Imaging for Mixed and Multiple Valvular Heart Disease
Alexandre Unger et al.
European Heart Journal - Imaging Methods and PracticeAccepted
For inquiries about collaboration, data access, or participation:
theopezel.eacvi@gmail.com